منابع مشابه
MAP kinase pathways.
Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate numerous proteins, including transcription factors, cytoskeletal proteins, kinases and other enzymes, and greatly influence gene expression, metabolism, cell division, cell morphology and cell survi...
متن کاملMAP kinase pathways.
Mitogen-activated protein kinase (MAPK) modules containing three sequentially activated protein kinases are key components of a series of vital signal transduction pathways that regulate processes such as cell proliferation, cell differentiation, and cell death in eukaryotes from yeast to humans (Fig. 1) (Qi and Elion 2005; Raman et al. 2007; Keshet and Seger 2010). Each cascade is initiated by...
متن کاملMap kinase signaling pathways and hematologic malignancies.
Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of Map kinases exist: the p38 Map kinase family, the extracellular signal-regulated kinase (Erk) family, and the c-Jun NH2-terminal kinase (JNK) family. The members of the different Map kinase groups participate in the generation of vari...
متن کاملAlteration of MAP kinase pathways after transient forebrain ischemia.
Extracellular regulated kinase (ERK) transduce growth factor signals while c-Jun NH(2)-terminal kinase (JNK) delivers stress signals into the nuclei for regulation of gene expression. These signaling pathways were studied by laser-scanning confocal microcopy and Western blot analysis using phospho-specific antibodies on rat brains that were subjected to 15 minutes transient forebrain ischemia f...
متن کاملMitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammali...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2005
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02470